Since 1963, we have consistently driven product development through scientific research. With 45+ years of continuous accumulation, 3 core patented technologies, and deep collaboration with Japan's top universities, every product has solid scientific evidence.
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🔬Science-Driven
Product development based on rigorous scientific research, referencing Nobel Prize winner Professor Tasuku Honjo's research field
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💎Quality First
GMP+ISO dual certification, fully traceable quality management system
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💡Continuous Innovation
45+ years of continuous R&D investment, 3+ core patented technologies
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🌏Global Collaboration
Deep collaboration with Japan's top universities, internationally recognized research results
R&D Milestones
The Iwade Fungology Research Institute was established, successfully cultivating Agaricus blazei "Iwade 101 strain," pioneering the systematic scientific research of Agaricus blazei. This breakthrough laid a solid foundation for decades of in-depth research.
Established deep collaboration with Japan's Mie University Graduate School of Medicine, jointly conducted multiple clinical studies with European and American research institutions. Continuously optimized extraction processes, accumulating rich scientific validation data and clinical experience.
Successfully developed subcritical water extraction technology and obtained patent (7141630), breaking through traditional high-temperature extraction bottlenecks. Subsequently obtained core patents including Tie2 pathway technology (6246859) and Livinol™ (5980228).
Over 45 years of research accumulation has established a complete R&D system. Products have obtained multiple international certifications including GMP, ISO, and FDA, sold to 10+ countries worldwide, continuously providing high-quality health products to global consumers.
Core Patented Technologies
Using subcritical water at 150-200°C and approximately 10MPa pressure as the extraction solvent, achieving efficient extraction while maintaining the integrity of active ingredients. Compared to traditional high-temperature extraction, active ingredient retention is improved by over 30%, with no chemical solvent residue. Jointly developed with Mie University, Japan.
By activating Tie2 receptors, it regulates vascular endothelial cell function and maintains vascular stability and integrity. Clinical research shows this technology helps promote microcirculation, improve peripheral circulation disorders, and relieve daily discomforts such as cold hands/feet and fatigue.
High-concentration Garcinol patented ingredient extracted from Garcinia. Multiple studies have verified its multiple health support functions including metabolic health support, cellular vitality maintenance, and body balance assistance. Mainly used in CP-101 Kangenriki products.
Using advanced enteric coating technology, capsules can resist gastric acid erosion and precisely release active ingredients in the specific pH environment of the intestine. Achieving targeted absorption, significantly improving bioavailability and maximizing product efficacy.
Research Highlights
In in vivo and in vitro experiments, CP-101 extract showed positive regulatory effects on immune-related cells. Research indicates the extract promotes specific molecular expression, enhances secretion of health defense-related components, with concentration-dependent effects. Experiments confirmed its contribution to maintaining body balance and health defense.
Clinical research shows that after taking CP-101 Kingo kohonmaru, subjects' skin surface temperature showed positive changes, suggesting potential for promoting smooth circulation. Tie2 pathway activation helps maintain healthy vascular conditions, regulate fluid balance, and relieve daily discomforts like cold hands and feet.
In animal experiments and early research models, continued intake of CP-101 Kangenriki showed positive changes in specific metabolic health-related indicators. Research suggests potential for maintaining healthy cell conditions, supporting overall metabolic capacity, and promoting healthy body shape maintenance.
Subjective feedback from real users shows that after continued use of CP-101 products, most users feel improved daily vitality, reduced fatigue, and better mental state. Some users also reported increased warmth in hands and feet, and improved overall satisfaction.
R&D Strength
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45+Years of Research
Continuous R&D since 1963
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3+Core Patents
Exclusive patented technology barriers
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2+University Partners
Deep collaboration with top universities
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100%Japanese Quality
Full GMP factory production
Research Partners
National Mie University is a research institution renowned in the fields of medicine and immunology. The university's Graduate School of Medicine participated in functional research of Agaricus blazei, making important contributions to the development and verification of subcritical water extraction technology. Professor Gabazza Esteban is our core research collaborator, and his team has achieved fruitful results in immune regulation mechanism research.
Established in 1963, this is the research institute that successfully cultivated Agaricus blazei "Iwade 101 strain," and is the origin of the CP-101 brand name. Over 60 years of professional research accumulation has made it an authoritative institution in global Agaricus blazei research. The institute continues in-depth research and academic verification of Agaricus blazei, providing a solid scientific foundation for our product development.